首页工具

登录

搜索结果

Search Results for " app secretase "

Targets Recommended: Beta Amyloid Caspase

16

抑制剂 & 化合物

1

TargetMol 试剂盒

4

重组蛋白

如果没找到您满意的产品或者您对产品有其他要求，可以联系我们专业顾问为您提供针对性的合理建议。 QQ咨询网站留言咨询

Cat. No.	Product Name	Form	Specificity Of Inhibition
CL0149	β-/γ-secretase inhibitor kit β-/γ-secretase inhibitor kit

TargetMol 试剂盒

β-/γ-secretase inhibitor kit

Cat.No: CL0149

Cat. No.	Product Name	Target	Signaling Pathways
T9713	δ-secretase inhibitor 11	Beta Amyloid; Caspase	Apoptosis; Neuroscience; Proteases/Proteasome
	δ-secretase inhibitor 11是一种分泌酶抑制剂，可用作阿尔茨海默病（AD）治疗转化开发的先导化合物。
T11178L	ELN318463 racemate ELN318463 (racemate),ELN 318463 racemate	Gamma-secretase	Neuroscience; Proteases/Proteasome; Stem Cells
	ELN318463 racemate (ELN 318463 racemate) 是 ELN318463 的外消旋体，ELN318463 是一种淀粉样前体蛋白 (APP) 选择性 γ-分泌酶抑制剂。
T14673	BMS 299897	Beta Amyloid; Gamma-secretase	Neuroscience; Proteases/Proteasome; Stem Cells
	BMS 299897 是一种磺胺类 γ 分泌酶抑制剂。它在稳定过表达淀粉样前体蛋白（APP）的 HEK293 细胞中抑制 Aβ 生成的 IC50 值为 7 nM。
T21890	JLK6	Gamma-secretase	Neuroscience; Proteases/Proteasome; Stem Cells
	JLK-6 是一种γ分泌酶抑制剂，选择性作用于 HEK293细胞的淀粉样β前体蛋白(APP)的γ-分泌酶裂解 APP，抑制 Aβ的生成，但对不 Notch 受体的裂解无影响。
T7011	Verubecestat MK-8931,维罗司他	Beta-Secretase; BACE	Neuroscience
	Verubecestat (MK-8931) 是一种高亲和力的、具有口服活性的BACE1和BACE2抑制剂，Ki 分别为 2.2 nM 和 0.38 nM。它可以有效降低 Aβ40，并具有潜力用于阿尔茨海默氏病。
T6870	L-685458 L-685,458	Apoptosis; Gamma-secretase	Apoptosis; Neuroscience; Proteases/Proteasome; Stem Cells
	L-685458 (L-685,458) 是一种过渡状态模拟 γ-分泌酶抑制剂，抑制淀粉样 β-蛋白前体 γ-分泌酶活性，选择性高于其他检测的天冬氨酸蛋白酶 50-100 倍。它抑制 γ-分泌酶介导的 APP-C99 和 Notch-100 的裂解，可研究阿尔茨海默病和癌症。
T24210	JNJ-40418677
	JNJ-40418677 is a γ-secretase modulator that selectively blocks γ-site cleavage of the APP without affecting the processing of Notch.
T70366	PF-06663195
	PF-06663195 is a potent inhibitor of β-site amyloid precursor protein (APP) Cleaving Enzyme 1 (BACE1, β-Secretase 1).
TP1099	M-2420 Methoxycoumarin-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Lys-dinitrophenyl
	M-2420 is a fluorogenic substrate designed specifically for the β-secretase site found in the Swedish mutation of the amyloid precursor protein (APP).
T11178	ELN318463 ELN 318463	Others	Others
	ELN 318463 shows differential inhibition of presenilin (PS1)- and PS2-comprised γ-secretase with EC50s of 12 nM and 656 nM for PS1 and PS2, respectively. ELN 318463 is 51-fold more selective for PS1.ELN 318463 is an amyloid precursor protein (APP) selective γ-secretase inhibitor.
T25685	Leucyl-phenylalanine amide Leu-phe-NH2
	Leucyl-phenylalanine amide is an intermediate in the synthesis of γ-Secretase Inhibitor, the enzyme complex that catalyzes the cleavage of the amyloid precursor protein (APP) to produce amyloid β-peptide (Aβ) which is the major causative agent in Alzheime
T69664	Umibecestat HCl
	Umibecestat, also known as CNP-520, is a beta-secretase inhibitor and is a drug candidate for prevention trials in Alzheimer's disease. CNP520 has a selectivity, pharmacodynamics, and distribution profile suitable for AD prevention studies. CNP520 reduced brain and cerebrospinal fluid (CSF) Aβ in rats and dogs, and Aβ plaque deposition in APP-transgenic mice. CNP520 reduces Aβ load and neuroinflammation in APP‐transgenic mice
T71899	Verubecestat TFA
	Verubecestat TFA, also known as MK-8931 or SCH 900931, is a potent and selective beta-secretase inhibitor, and BACE1 protein inhibitor or Beta-site APP-cleaving enzyme 1 inhibitor. Verubecestat TFA is a promising novel therapeutic drug candidate in Alzheimer's disease. Verubecestat TFA reduced Aβ cerebral spinal fluids (CSF) levels up to 92% and was well tolerated by patients.
T70104	Verubecestat tosylate
	Verubecestat tosylate, also known as MK-8931 or SCH 900931, is a potent and selective beta-secretase inhibitor, and BACE1 protein inhibitor or Beta-site APP-cleaving enzyme 1 inhibitor. Verubecestat tosylate is a promising novel therapeutic drug candidate in Alzheimer's disease. Verubecestat tosylate reduced Aβ cerebral spinal fluids (CSF) levels up to 92% and was well tolerated by patients.
T37661	LY 2886721 Hydrochloride
	Potent and selective β-secretase (BACE) inhibitor (IC50 values are 10.2 and 20.3 nM for human BACE2 and BACE1, respectively). Displays >5,000-fold selectivity for BACE over other proteases including cathepsin D, pepsin and renin. Inhibits Aβ1-40 and Aβ1-42 production in cells expressing mutated APP. Reduces hippocampal and cortical Aβ and sAPPβ levels in an Alzheimer's disease mouse model.
T76393	Amyloid 17-42
	Amyloid 17-42 (Aβ(17-42))，作为阿尔茨海默病中弥漫性斑块与唐氏综合症小脑前区的主要淀粉样蛋白成分，源于淀粉样蛋白前体蛋白(APP)经α与γ分泌酶的裂解作用。此外，Amyloid 17-42能通过Fas样/caspase-8途径促使神经细胞发生凋亡。

化合物

δ-secretase inhibitor 11

Cat.No: T9713

Target: Beta Amyloid, Caspase

ELN318463 racemate

Cat.No: T11178L

Synonym: ELN318463 (racemate),ELN 318463 racemate

Target: Gamma-secretase

Cat.No: T14673

Target: Beta Amyloid, Gamma-secretase

Cat.No: T21890

Target: Gamma-secretase

Cat.No: T7011

Synonym: MK-8931,维罗司他

Target: Beta-Secretase, BACE

Cat.No: T6870

Synonym: L-685,458

Target: Apoptosis, Gamma-secretase

Cat.No: T24210

Cat.No: T70366

Cat.No: TP1099

Synonym: Methoxycoumarin-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Lys-dinitrophenyl

Cat.No: T11178

Synonym: ELN 318463

Target: Others

Leucyl-phenylalanine amide

Cat.No: T25685

Synonym: Leu-phe-NH2

Umibecestat HCl

Cat.No: T69664

Verubecestat TFA

Cat.No: T71899

Verubecestat tosylate

Cat.No: T70104

LY 2886721 Hydrochloride

Cat.No: T37661

Cat.No: T76393

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-00497	CTSB Protein, Human, Recombinant (His) APPS,CPSB,APP Secretase,Cathepsin...	Human	HEK293 Cells
	Cathepsin B is an enzymatic protein belonging to the peptidase (or protease) families. The protein encoded by this gene is a lysosomal cysteine protease composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It is a member of the peptidase C1 family. At least five transcript variants encoding the same protein have been found for this gene. Cystatin-B / CSTB is an intracellular thiol proteinase inhibitor. Tightly binding reversible inhibitor...
TMPH-01059	Cathepsin B Protein, Human, Recombinant (GST) Cathepsin B1,APPS,Cathepsin B,CPSB,APP	Human	E. coli
	Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Cleaves matrix extracellular phosphoglycoprotein MEPE. Involved in the solubilization of cross-linked TG/thyroglobulin in the thyroid follicle lumen. Has also been implicated in tumor invasion and metastasis. Cathepsin B Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 54.6 kDa and the accession number is P07858.
TMPJ-00358	DR6 Protein, Mouse, Recombinant (hFc & His) BM-018,CD358,DR6,Tnfrsf21,Tumor necrosis factor receptor sup...	Mouse	HEK293 Cells
	Tumor necrosis factor receptor superfamily member 21(DR6) is a single-pass type I membrane protein and contains 1 death domain and 4 TNFR-Cys repeats. The protein may activate NF-kappa-B and promote apoptosis and it may activate JNK and be involved in T-cell differentiation.It is required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragm...
TMPJ-00782	Amyloid Precursor Protein, Human, Recombinant (hFc) Amyloid Precursor,Amyloid Precursor Protein 695,APP...	Human	HEK293 Cells
	Amyloid precursor protein (APP) is a type I membrane protein with several isoforms due to alternative splicing, performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Of the three major splice isoforms of APP (APP695, APP751, and APP770) APP695 is the predominant neuronal form from which Amyloid beta peptide and transcriptionally-active cleaved intracellular domain of APP (AICD) are preferentially generated by selective process...

重组蛋白

CTSB Protein, Human, Recombinant (His)

Cat.No: TMPJ-00497

Species: Human

Expression System: HEK293 Cells

Cathepsin B Protein, Human, Recombinant (GST)

Cat.No: TMPH-01059

Species: Human

Expression System: E. coli

DR6 Protein, Mouse, Recombinant (hFc & His)

Cat.No: TMPJ-00358

Species: Mouse

Expression System: HEK293 Cells

Amyloid Precursor Protein, Human, Recombinant (hFc)

Cat.No: TMPJ-00782

Species: Human

Expression System: HEK293 Cells

我们的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

Copyright © 2015-2024 TargetMol Chemicals Inc. All rights reserved. 沪ICP备20019793号-4

沪公网安备 31010602006700号

沪公网安备 31010602006700号

TargetMol Loading

联系我们

电话：

400-820-0310

邮箱：

service@tsbiochem.com

QQ：

2881945090（终端用户）

2885109491（经销商）

经销：

终端：

地址：

上海市静安区江场三路238号8楼